Breast Cancer is a major cause of death worldwide among women. Hematoxylin and Eosin (H&E) stained breast tissue samples from biopsies are observed under microscopes for the primary diagnosis of breast cancer. In this paper, we propose a deep learning-based method for classification of H&E stained breast tissue images released for BACH challenge 2018 by fine-tuning Inception-v3 convolutional neural network (CNN) proposed by Szegedy et al. These images are to be classified into four classes namely, i) normal tissue, ii) benign tumor, iii) in-situ carcinoma and iv) invasive carcinoma. Our strategy is to extract patches based on nuclei density instead of random or grid sampling, along with rejection of patches that are not rich in nuclei (non-epithelial) regions for training and testing. Every patch (nuclei-dense region) in an image is classified in one of the four above mentioned categories. The class of the entire image is determined using majority voting over the nuclear classes. We obtained an average four class accuracy of 85% and an average two class (non-cancer vs. carcinoma) accuracy of 93%, which improves upon a previous benchmark by Araujo et al.

本研究利用深度学习方法，通过提取细胞核密度区域进行分类，通过 fine-tuning 原始的 Inception-v3 卷积神经网络，从而达到了对四种类型的 H&E 染色乳腺组织图像进行分类，并获得了高达 85% 的整体精确度和 93% 的癌症诊断精确度。

深度学习在乳腺癌组织学分类中的应用