The wide implementation of electronic health record (EHR) systems facilitates the collection of large-scale health data from real clinical settings. Despite the significant increase in adoption of EHR systems, this data remains largely unexplored, but presents a rich data source for knowledge discovery from patient health histories in tasks such as understanding disease correlations and predicting health outcomes. However, the heterogeneity, sparsity, noise, and bias in this data present many complex challenges. This complexity makes it difficult to translate potentially relevant information into machine learning algorithms. In this paper, we propose a computational framework, Patient2Vec, to learn an interpretable deep representation of longitudinal EHR data which is personalized for each patient. To evaluate this approach, we apply it to the prediction of future hospitalizations using real EHR data and compare its predictive performance with baseline methods. Patient2Vec produces a vector space with meaningful structure and it achieves an AUC around 0.799 outperforming baseline methods. In the end, the learned feature importance can be visualized and interpreted at both the individual and population levels to bring clinical insights.

本文提出了一种计算框架，称为Patient2Vec，以学习可解释的深度纵向电子健康记录数据表达，并将其应用于实际患者信息以预测未来住院情况，该方法展现出明显的预测性能优势。

Patient2Vec：长期电子健康记录的个性化可解释深度表示