Transposable Elements (TEs) or jumping genes are the DNA sequences that have an intrinsic capability to move within a host genome from one genomic location to another. Studies show that the presence of a TE within or adjacent to a functional gene may alter its expression. TEs can also cause an increase in the rate of mutation and can even mediate duplications and large insertions and deletions in the genome, promoting gross genetic rearrangements. Thus, the proper classification of the identified jumping genes is essential to understand their genetic and evolutionary effects in the genome. While computational methods have been developed that perform either binary classification or multi-label classification of TEs, few studies have focused on their hierarchical classification. The state-of-the-art machine learning classification method utilizes a Multi-Layer Perceptron (MLP), a class of neural network, for hierarchical classification of TEs. However, the existing methods have limited accuracy in classifying TEs. A more effective classifier, which can explain the role of TEs in germline and somatic evolution, is needed. In this study, we examine the performance of a variety of machine learning (ML) methods. And eventually, propose a robust approach for the hierarchical classification of TEs, with higher accuracy, using Support Vector Machines (SVM).

该研究旨在通过比较不同机器学习方法的表现，提出一种基于支持向量机（SVM）的有效的转座因子（Transposable Elements）分类方法，以更准确地理解它们在基因组中的遗传和进化效应。

基于机器学习的可转位元件分层分类预测