Spatial arrangement of cells of various types, such as tumor infiltrating lymphocytes and the advancing edge of a tumor, are important features for detecting and characterizing cancers. However, convolutional neural networks (CNNs) do not explicitly extract intricate features of the spatial arrangements of the cells from histopathology images. In this work, we propose to classify cancers using graph convolutional networks (GCNs) by modeling a tissue section as a multi-attributed spatial graph of its constituent cells. Cells are detected using their nuclei in H&E stained tissue image, and each cell's appearance is captured as a multi-attributed high-dimensional vertex feature. The spatial relations between neighboring cells are captured as edge features based on their distances in a graph. We demonstrate the utility of this approach by obtaining classification accuracy that is competitive with CNNs, specifically, Inception-v3, on two tasks-cancerous versus non-cancerous and in situ versus invasive-on the BACH breast cancer dataset.

本论文在组织切片图像中，使用图卷积网络 (Graph Convolutional Networks, GCNs) 对细胞的多属性空间图进行建模，通过提取细胞空间排列的复杂特征以实现肿瘤分类，得到了与 Inception-v3 相当的分类准确率。

组织病理学中的直方图图表