Machine learning (ML) research has yielded powerful tools for training accurate prediction models despite complex multivariate associations (e.g. interactions and heterogeneity). In fields such as medicine, improved interpretability of ML modeling is required for knowledge discovery, accountability, and fairness. Rule-based ML approaches such as Learning Classifier Systems (LCSs) strike a balance between predictive performance and interpretability in complex, noisy domains. This work introduces the LCS Discovery and Visualization Environment (LCS-DIVE), an automated LCS model interpretation pipeline for complex biomedical classification. LCS-DIVE conducts modeling using a new scikit-learn implementation of ExSTraCS, an LCS designed to overcome noise and scalability in biomedical data mining yielding human readable IF:THEN rules as well as feature-tracking scores for each training sample. LCS-DIVE leverages feature-tracking scores and/or rules to automatically guide characterization of (1) feature importance (2) underlying additive, epistatic, and/or heterogeneous patterns of association, and (3) model-driven heterogeneous instance subgroups via clustering, visualization generation, and cluster interrogation. LCS-DIVE was evaluated over a diverse set of simulated genetic and benchmark datasets encoding a variety of complex multivariate associations, demonstrating its ability to differentiate between them and then applied to characterize associations within a real-world study of pancreatic cancer.

介绍了一种用于生物医学分类的新型自动化学习分类系统（LCS-DIVE），可自动指导特征重要性、底层加性、上位互作和/或异质模式的表征，通过聚类、可视化生成和簇切入来生成可读性良好的IF:THEN规则，以及每个训练样本的特征追踪分数。

LCS-DIVE: 一种用于分类复杂关联特征表征的自动化基于规则的机器学习可视化流程