Image-to-image translation is an ill-posed problem as unique one-to-one mapping may not exist between the source and target images. Learning-based methods proposed in this context often evaluate the performance on test data that is similar to the training data, which may be impractical. This demands robust methods that can quantify uncertainty in the prediction for making informed decisions, especially for critical areas such as medical imaging. Recent works that employ conditional generative adversarial networks (GANs) have shown improved performance in learning photo-realistic image-to-image mappings between the source and the target images. However, these methods do not focus on (i)~robustness of the models to out-of-distribution (OOD)-noisy data and (ii)~uncertainty quantification. This paper proposes a GAN-based framework that (i)~models an adaptive loss function for robustness to OOD-noisy data that automatically tunes the spatially varying norm for penalizing the residuals and (ii)~estimates the per-voxel uncertainty in the predictions. We demonstrate our method on two key applications in medical imaging: (i)~undersampled magnetic resonance imaging (MRI) reconstruction (ii)~MRI modality propagation. Our experiments with two different real-world datasets show that the proposed method (i)~is robust to OOD-noisy test data and provides improved accuracy and (ii)~quantifies voxel-level uncertainty in the predictions.

本文提出了一种基于GAN的框架，其中(i)模型自适应损失函数以提高模型对OOD-噪声数据的鲁棒性，(ii)对预测的每个体素的不确定性进行了估计，在医学成像领域表现出优异的性能。

具有自适应损失的不确定性感知 GAN 用于稳健的 MRI 图像增强