Magnetic resonance imaging (MRI) is a common and life-saving medical imaging technique. However, acquiring high signal-to-noise ratio MRI scans requires long scan times, resulting in increased costs and patient discomfort, and decreased throughput. Thus, there is great interest in denoising MRI scans, especially for the subtype of diffusion MRI scans that are severely SNR-limited. While most prior MRI denoising methods are supervised in nature, acquiring supervised training datasets for the multitude of anatomies, MRI scanners, and scan parameters proves impractical. Here, we propose Denoising Diffusion Models for Denoising Diffusion MRI (DDM$^2$), a self-supervised denoising method for MRI denoising using diffusion denoising generative models. Our three-stage framework integrates statistic-based denoising theory into diffusion models and performs denoising through conditional generation. During inference, we represent input noisy measurements as a sample from an intermediate posterior distribution within the diffusion Markov chain. We conduct experiments on 4 real-world in-vivo diffusion MRI datasets and show that our DDM$^2$ demonstrates superior denoising performances ascertained with clinically-relevant visual qualitative and quantitative metrics.

该论文提出了一种自监督的去噪磁共振成像方法，称为DDM^2，通过将统计基础的去噪理论整合到扩散模型中，采用条件生成实现去噪。在实验中，该方法在4个真实的体内扩散MRI数据集上展现了卓越的去噪性能，用临床相关的定量和定性指标进行评估。

DDM$^2$: 用生成性扩散模型进行自监督扩散 MRI 去噪