In practice, digital pathology images are often affected by various factors, resulting in very large differences in color and brightness. Stain normalization can effectively reduce the differences in color and brightness of digital pathology images, thus improving the performance of computer-aided diagnostic systems. Conventional stain normalization methods rely on one or several reference images, but one or several images are difficult to represent the entire dataset. Although learning-based stain normalization methods are a general approach, they use complex deep networks, which not only greatly reduce computational efficiency, but also risk introducing artifacts. StainNet is a fast and robust stain normalization network, but it has not a sufficient capability for complex stain normalization due to its too simple network structure. In this study, we proposed a parameter-variable stain normalization network, ParamNet. ParamNet contains a parameter prediction sub-network and a color mapping sub-network, where the parameter prediction sub-network can automatically determine the appropriate parameters for the color mapping sub-network according to each input image. The feature of parameter variable ensures that our network has a sufficient capability for various stain normalization tasks. The color mapping sub-network is a fully 1x1 convolutional network with a total of 59 variable parameters, which allows our network to be extremely computationally efficient and does not introduce artifacts. The results on cytopathology and histopathology datasets show that our ParamNet outperforms state-of-the-art methods and can effectively improve the generalization of classifiers on pathology diagnosis tasks. The code has been available at https://github.com/khtao/ParamNet.

本研究提出了基于参数可变的深度学习网络ParamNet，用于数字病理学图像的染色归一化，该网络能够提高诊断系统的性能和分类器的泛化能力，同时保持计算效率和图像质量。

ParamNet: 快速染色标准化的参数可变网络