The brain is likely the most complex organ, given the variety of functions it controls, the number of cells it comprises, and their corresponding diversity. Studying and identifying neurons, the brain's primary building blocks, is a crucial milestone and essential for understanding brain function in health and disease. Recent developments in machine learning have provided advanced abilities for classifying neurons. However, these methods remain black boxes with no explainability and reasoning. This paper aims to provide a robust and explainable deep-learning framework to classify neurons based on their electrophysiological activity. Our analysis is performed on data provided by the Allen Cell Types database containing a survey of biological features derived from single-cell recordings of mice and humans. First, we classify neuronal cell types of mice data to identify excitatory and inhibitory neurons. Then, neurons are categorized to their broad types in humans using domain adaptation from mice data. Lastly, neurons are classified into sub-types based on transgenic mouse lines using deep neural networks in an explainable fashion. We show state-of-the-art results in a dendrite-type classification of excitatory vs. inhibitory neurons and transgenic mouse lines classification. The model is also inherently interpretable, revealing the correlations between neuronal types and their electrophysiological properties.

使用深度学习框架和Allen细胞类型数据库，对小鼠和人类的神经元进行分类，实现了解释性和推理，同时发现了神经元类型与其电生理特性之间的相关性。

使用深度学习进行神经元细胞类型分类