Advancements in digital pathology and computing resources have made a significant impact in the field of computational pathology for breast cancer diagnosis and treatment. However, access to high-quality labeled histopathological images of breast cancer is a big challenge that limits the development of accurate and robust deep learning models. In this systematic review, we identified the publicly available datasets of breast H&E stained whole-slide images (WSI) that can be used to develop deep learning algorithms. We systematically searched nine scientific literature databases and nine research data repositories. We found twelve publicly available datasets, containing 5153 H&E WSIs of breast cancer. Moreover, we reported image metadata and characteristics for each dataset to assist researchers in selecting proper datasets for specific tasks in breast cancer computational pathology. In addition, we compiled a list of patch and private datasets that were used in the included articles as a supplementary resource for researchers. Notably, 22% of the included articles utilized multiple datasets, and only 12% of the articles used an external validation set, suggesting that the performance of other developed models may be susceptible to overestimation. The TCGA-BRCA was used in 47.4% of the selected studies. This dataset has a considerable selection bias that can impact the robustness and generalizability of the trained algorithms. There is also a lack of consistent metadata reporting of breast WSI datasets that can be an issue in developing accurate deep learning models, indicating the necessity of establishing explicit guidelines for documenting breast WSI dataset characteristics and metadata.

通过对乳腺癌组织标本图像的数据集进行系统回顾，发现了12个公开的数据集，并对每个数据集的元数据和特征进行了报告，同时编制了一个文章中使用的补充资源列表。此外，还强调了建立乳腺癌WSI数据集元数据报告指南的必要性。

乳腺组织病理学H&E全切片图像的公开数据集：系统综述