Denoising diffusion models have found applications in image segmentation by generating segmented masks conditioned on images. Existing studies predominantly focus on adjusting model architecture or improving inference such as test-time sampling strategies. In this work, we focus on training strategy improvements and propose a novel recycling method. During each training step, a segmentation mask is first predicted given an image and a random noise. This predicted mask, replacing the conventional ground truth mask, is used for denoising task during training. This approach can be interpreted as aligning the training strategy with inference by eliminating the dependence on ground truth masks for generating noisy samples. Our proposed method significantly outperforms standard diffusion training, self-conditioning, and existing recycling strategies across multiple medical imaging data sets: muscle ultrasound, abdominal CT, prostate MR, and brain MR. This holds true for two widely adopted sampling strategies: denoising diffusion probabilistic model and denoising diffusion implicit model. Importantly, existing diffusion models often display a declining or unstable performance during inference, whereas our novel recycling consistently enhances or maintains performance. Furthermore, we show for the first time that, under a fair comparison with the same network architectures and computing budget, the proposed recycling-based diffusion models achieved on-par performance with non-diffusion-based supervised training. This paper summarises these quantitative results and discusses their values, with a fully reproducible JAX-based implementation, released at https://github.com/mathpluscode/ImgX-DiffSeg.

通过改进训练策略和提出一种新的回收方法，本文旨在解决现有扩散模型在图像分割中的性能问题，实验证明该方法在多个医学影像数据集上显著优于标准扩散训练，改善了性能并与非扩散型监督训练相媲美。

使用扩散去噪模型的医学图像分割回收训练策略