The proliferation of data in recent years has led to the advancement and utilization of various statistical and deep learning techniques, thus expediting research and development activities. However, not all industries have benefited equally from the surge in data availability, partly due to legal restrictions on data usage and privacy regulations, such as in medicine. To address this issue, various statistical disclosure and privacy-preserving methods have been proposed, including the use of synthetic data generation. Synthetic data are generated based on some existing data, with the aim of replicating them as closely as possible and acting as a proxy for real sensitive data. This paper presents a systematic review of methods for generating and evaluating synthetic longitudinal patient data, a prevalent data type in medicine. The review adheres to the PRISMA guidelines and covers literature from five databases until the end of 2022. The paper describes 17 methods, ranging from traditional simulation techniques to modern deep learning methods. The collected information includes, but is not limited to, method type, source code availability, and approaches used to assess resemblance, utility, and privacy. Furthermore, the paper discusses practical guidelines and key considerations for developing synthetic longitudinal data generation methods.

通过系统回顾方法，本文介绍了在医学领域中生成和评估综合性纵向患者数据的17种方法，涵盖了从传统模拟技术到现代深度学习方法的范围，并讨论了开发综合性纵向数据生成方法的实际指南和关键考虑因素。

生成和评估合成纵向患者数据的方法：系统综述