Cortical surface analysis has gained increased prominence, given its potential implications for neurological and developmental disorders. Traditional vision diffusion models, while effective in generating natural images, present limitations in capturing intricate development patterns in neuroimaging due to limited datasets. This is particularly true for generating cortical surfaces where individual variability in cortical morphology is high, leading to an urgent need for better methods to model brain development and diverse variability inherent across different individuals. In this work, we proposed a novel diffusion model for the generation of cortical surface metrics, using modified surface vision transformers as the principal architecture. We validate our method in the developing Human Connectome Project (dHCP), the results suggest our model demonstrates superior performance in capturing the intricate details of evolving cortical surfaces. Furthermore, our model can generate high-quality realistic samples of cortical surfaces conditioned on postmenstrual age(PMA) at scan.

在这项研究中，我们提出了一种基于修改后的表面视觉转换模型作为主要架构的新型扩散模型，用于生成大脑皮层表面度量。我们在发育中的人类连接组计划(dHCP)中验证了我们的方法，结果表明我们的模型在捕捉变化中的大脑皮层表面的复杂细节方面表现出优越性能。此外，我们的模型可以在扫描时根据孕周龄(PMA)生成高质量、逼真的皮层表面样本。

皮层表面扩散生成模型