In this work, we aim to predict the survival time (ST) of glioblastoma (GBM) patients undergoing different treatments based on preoperative magnetic resonance (MR) scans. The personalized and precise treatment planning can be achieved by comparing the ST of different treatments. It is well established that both the current status of the patient (as represented by the MR scans) and the choice of treatment are the cause of ST. While previous related MR-based glioblastoma ST studies have focused only on the direct mapping of MR scans to ST, they have not included the underlying causal relationship between treatments and ST. To address this limitation, we propose a treatment-conditioned regression model for glioblastoma ST that incorporates treatment information in addition to MR scans. Our approach allows us to effectively utilize the data from all of the treatments in a unified manner, rather than having to train separate models for each of the treatments. Furthermore, treatment can be effectively injected into each convolutional layer through the adaptive instance normalization we employ. We evaluate our framework on the BraTS20 ST prediction task. Three treatment options are considered: Gross Total Resection (GTR), Subtotal Resection (STR), and no resection. The evaluation results demonstrate the effectiveness of injecting the treatment for estimating GBM survival.

我们提出了一种治疗条件回归模型，利用术前磁共振扫描预测胶质母细胞瘤患者的生存时间。通过将治疗信息与磁共振扫描结合起来，我们的方法有效利用了所有治疗数据，并证明了将治疗注入到每个卷积层中的有效性。

多参数术前核磁共振影像对细胞母细胞瘤生存推断的治疗方向