Medical data often exhibits distribution shifts, which cause test-time performance degradation for deep learning models trained using standard supervised learning pipelines. This challenge is addressed in the field of Domain Generalization (DG) with the sub-field of Single Domain Generalization (SDG) being specifically interesting due to the privacy- or logistics-related issues often associated with medical data. Existing disentanglement-based SDG methods heavily rely on structural information embedded in segmentation masks, however classification labels do not provide such dense information. This work introduces a novel SDG method aimed at medical image classification that leverages channel-wise contrastive disentanglement. It is further enhanced with reconstruction-based style regularization to ensure extraction of distinct style and structure feature representations. We evaluate our method on the complex task of multicenter histopathology image classification, comparing it against state-of-the-art (SOTA) SDG baselines. Results demonstrate that our method surpasses the SOTA by a margin of 1% in average accuracy while also showing more stable performance. This study highlights the importance and challenges of exploring SDG frameworks in the context of the classification task. The code is publicly available at https://github.com/BioMedIA-MBZUAI/ConDiSR

医学数据在分布上经常发生变化，这会导致采用标准监督学习流程训练的深度学习模型在测试时性能下降。本研究介绍了一种新的医学图像分类的单域泛化方法，它利用了通道间的对比解缠绕，并通过基于重构的样式正则化进一步增强了独立的样式和结构特征表示的提取。我们将该方法在多中心组织病理图像分类的复杂任务上进行了评估，与最先进的单域泛化基线进行了比较。结果表明，我们的方法在平均准确率上超过了最先进的方法1％，同时表现更稳定，突显了在分类任务背景下探索单域泛化框架的重要性和挑战。

ConDiSR：单域泛化的对比解缠和风格规范化