Deep learning enables the modelling of high-resolution histopathology whole-slide images (WSI). Weakly supervised learning of tile-level data is typically applied for tasks where labels only exist on the patient or WSI level (e.g. patient outcomes or histological grading). In this context, there is a need for improved spatial interpretability of predictions from such models. We propose a novel method, Wsi rEgion sElection aPproach (WEEP), for model interpretation. It provides a principled yet straightforward way to establish the spatial area of WSI required for assigning a particular prediction label. We demonstrate WEEP on a binary classification task in the area of breast cancer computational pathology. WEEP is easy to implement, is directly connected to the model-based decision process, and offers information relevant to both research and diagnostic applications.

利用深度学习对高分辨率组织病理学全幻灯片图像进行建模，提出一种适用于模型解读的方法，Wsi rEgion sElection aPproach (WEEP)，该方法能够准确确定用于预测特定标签所需的WSI空间范围，并且在乳腺癌计算病理学领域的二分类任务中进行了演示。

WEEP：一种计算机病理学中弱监督卷积神经网络模型的空间解释方法