It seems that in the current age, computers, computation, and data have an increasingly important role to play in scientific research and discovery. This is reflected in part by the rise of machine learning and artificial intelligence, which have become great areas of interest not just for computer science but also for many other fields of study. More generally, there have been trends moving towards the use of bigger, more complex and higher capacity models. It also seems that stochastic models, and stochastic variants of existing deterministic models, have become important research directions in various fields. For all of these types of models, gradient-based optimization remains as the dominant paradigm for model fitting, control, and more. This dissertation considers unconstrained, nonlinear optimization problems, with a focus on the gradient itself, that key quantity which enables the solution of such problems. In chapter 1, we introduce the notion of reverse differentiation, a term which describes the body of techniques which enables the efficient computation of gradients. We cover relevant techniques both in the deterministic and stochastic cases. We present a new framework for calculating the gradient of problems which involve both deterministic and stochastic elements. In chapter 2, we analyze the properties of the gradient estimator, with a focus on those properties which are typically assumed in convergence proofs of optimization algorithms. Chapter 3 gives various examples of applying our new gradient estimator. We further explore the idea of working with piecewise continuous models, that is, models with distinct branches and if statements which define what specific branch to use.

在当今时代，计算机、计算和数据在科学研究和发现中的重要性不断增加。本论文主要关注梯度本身，解决非线性优化问题，并介绍了逆向微分的概念和应用，以及分段连续模型的使用案例。

随机和确定模型中的渐变估计和方差减少