H&E-to-IHC stain translation techniques offer a promising solution for precise cancer diagnosis, especially in low-resource regions where there is a shortage of health professionals and limited access to expensive equipment. Considering the pixel-level misalignment of H&E-IHC image pairs, current research explores the pathological consistency between patches from the same positions of the image pair. However, most of them overemphasize the correspondence between domains or patches, overlooking the side information provided by the non-corresponding objects. In this paper, we propose a Mix-Domain Contrastive Learning (MDCL) method to leverage the supervision information in unpaired H&E-to-IHC stain translation. Specifically, the proposed MDCL method aggregates the inter-domain and intra-domain pathology information by estimating the correlation between the anchor patch and all the patches from the matching images, encouraging the network to learn additional contrastive knowledge from mixed domains. With the mix-domain pathology information aggregation, MDCL enhances the pathological consistency between the corresponding patches and the component discrepancy of the patches from the different positions of the generated IHC image. Extensive experiments on two H&E-to-IHC stain translation datasets, namely MIST and BCI, demonstrate that the proposed method achieves state-of-the-art performance across multiple metrics.

通过提出混合域对比学习（MDCL）方法，在未配对的H&E到IHC染色转换中利用不同领域的病理信息聚合，提高相应补丁之间的病理一致性和生成的IHC图像不同位置的补丁的不一致性组件，取得了多个度量标准下的最先进性能。

跨领域对比学习用于无配对的H&E到IHC染色转换