Cancer clinics capture disease data at various scales, from genetic to organ
level. Current bioinformatic methods struggle to handle the heterogeneous
nature of this data, especially with missing modalities. We propose PARADIGM, a
Graph Neural Network (GNN) framework that learns from multimodal, heterogeneous
datasets to improve clinical outcome prediction. PARADIGM generates embeddings
from multi-resolution data using foundation models, aggregates them into
patient-level representations, fuses them into a unified graph, and enhances
performance for tasks like survival analysis. We train GNNs on pan-Squamous
Cell Carcinomas and validate our approach on Moffitt Cancer Center lung SCC
data. Multimodal GNN outperforms other models in patient survival prediction.
Converging individual data modalities across varying scales provides a more
insightful disease view. Our solution aims to understand the patient's
circumstances comprehensively, offering insights on heterogeneous data
integration and the benefits of converging maximum data views.

用于患者生存预测的基于多模态数据的图神经网络框架 PARADIGM 优于其他模型，通过整合多种数据视角，提供全面的疾病认知。