Virtual Reality (VR) has emerged as a promising tool for enhancing social
skills and emotional well-being in individuals with Autism Spectrum Disorder
(ASD). Through a technical exploration, this study employs a multiplayer
serious gaming environment within VR, engaging 34 individuals diagnosed with
ASD and employing high-precision biosensors for a comprehensive view of the
participants' arousal and responses during the VR sessions. Participants were
subjected to a series of 3 virtual scenarios designed in collaboration with
stakeholders and clinical experts to promote socio-cognitive skills and
emotional regulation in a controlled and structured virtual environment. We
combined the framework with wearable non-invasive sensors for bio-signal
acquisition, focusing on the collection of heart rate variability, and
respiratory patterns to monitor participants behaviors. Further, behavioral
assessments were conducted using observation and semi-structured interviews,
with the data analyzed in conjunction with physiological measures to identify
correlations and explore digital-intervention efficacy. Preliminary analysis
revealed significant correlations between physiological responses and
behavioral outcomes, indicating the potential of physiological feedback to
enhance VR-based interventions for ASD. The study demonstrated the feasibility
of using real-time data to adapt virtual scenarios, suggesting a promising
avenue to support personalized therapy. The integration of quantitative
physiological feedback into digital platforms represents a forward step in the
personalized intervention for ASD. By leveraging real-time data to adjust
therapeutic content, this approach promises to enhance the efficacy and
engagement of digital-based therapies.

使用虚拟现实技术结合生理反馈通过多人在线游戏环境对诊断为自闭症谱系障碍的 34 名个体进行研究，结果显示生理反应与行为结果存在显著相关性，表明生理反馈有潜力增强基于虚拟现实的自闭症干预的效果。通过利用实时数据调整治疗内容，该方法有望提高数字化治疗的功效和参与度。