Deformable templates are essential to large-scale medical image registration,
segmentation, and population analysis. Current conventional and deep
network-based methods for template construction use only regularized
registration objectives and often yield templates with blurry and/or
anatomically implausible appearance, confounding downstream biomedical
interpretation. We reformulate deformable registration and conditional template
estimation as an adversarial game wherein we encourage realism in the moved
templates with a generative adversarial registration framework conditioned on
flexible image covariates. The resulting templates exhibit significant gain in
specificity to attributes such as age and disease, better fit underlying
group-wise spatiotemporal trends, and achieve improved sharpness and
centrality. These improvements enable more accurate population modeling with
diverse covariates for standardized downstream analyses and easier anatomical
delineation for structures of interest.

通过在生成敌对式登录框架中利用灵活的图像协变量 - 使得移动的模板更真实，作者重新制定了可变形模板，以获得更好的特异性和适应性，该模板能更好地拟合潜在的群体空间 - 时间趋势，并使解剖学结构更容易划分。