Epilepsy is one of the most serious neurological diseases, affecting 1-2% of
the world's population. The diagnosis of epilepsy depends heavily on the
recognition of epileptic waves, i.e., disordered electrical brainwave activity
in the patient's brain. Existing works have begun to employ machine learning
models to detect epileptic waves via cortical electroencephalogram (EEG).
However, the recently developed stereoelectrocorticography (SEEG) method
provides information in stereo that is more precise than conventional EEG, and
has been broadly applied in clinical practice. Therefore, we propose the first
data-driven study to detect epileptic waves in a real-world SEEG dataset. While
offering new opportunities, SEEG also poses several challenges. In clinical
practice, epileptic wave activities are considered to propagate between
different regions in the brain. These propagation paths, also known as the
epileptogenic network, are deemed to be a key factor in the context of epilepsy
surgery. However, the question of how to extract an exact epileptogenic network
for each patient remains an open problem in the field of neuroscience. To
address these challenges, we propose a novel model (BrainNet) that jointly
learns the dynamic diffusion graphs and models the brain wave diffusion
patterns. In addition, our model effectively aids in resisting label imbalance
and severe noise by employing several self-supervised learning tasks and a
hierarchical framework. By experimenting with the extensive real SEEG dataset
obtained from multiple patients, we find that BrainNet outperforms several
latest state-of-the-art baselines derived from time-series analysis.

该研究提出了一种名为 BrainNet 的新型模型，通过联合学习动态扩散图和建模脑电波扩散模式的方式，有效地帮助抵抗 SEEG 数据中的标签失衡和严重噪声问题， 并超过了时间序列分析的最新一流基线模型，以探测实际的 SEEG 数据集中的癫痫波。

BrainNet: 使用层次图扩散学习从 SEEG 中检测癫痫波

BrainNet: Epileptic Wave Detection from SEEG with Hierarchical Graph  Diffusion Learning

Brain signals are important quantitative data for understanding physiological
activities and diseases of human brain. Most existing studies pay attention to
supervised learning methods, which, however, require high-cost clinical labels.
In addition, the huge difference in the clinical patterns of brain signals
measured by invasive (e.g., SEEG) and non-invasive (e.g., EEG) methods leads to
the lack of a unified method. To handle the above issues, we propose to study
the self-supervised learning (SSL) framework for brain signals that can be
applied to pre-train either SEEG or EEG data. Intuitively, brain signals,
generated by the firing of neurons, are transmitted among different connecting
structures in human brain. Inspired by this, we propose MBrain to learn
implicit spatial and temporal correlations between different channels (i.e.,
contacts of the electrode, corresponding to different brain areas) as the
cornerstone for uniformly modeling different types of brain signals.
Specifically, we represent the spatial correlation by a graph structure, which
is built with proposed multi-channel CPC. We theoretically prove that
optimizing the goal of multi-channel CPC can lead to a better predictive
representation and apply the instantaneou-time-shift prediction task based on
it. Then we capture the temporal correlation by designing the
delayed-time-shift prediction task. Finally, replace-discriminative-learning
task is proposed to preserve the characteristics of each channel. Extensive
experiments of seizure detection on both EEG and SEEG large-scale real-world
datasets demonstrate that our model outperforms several state-of-the-art time
series SSL and unsupervised models, and has the ability to be deployed to
clinical practice.

本文提出了 MBrain，一种用于自监督学习的框架，可以用于预训练 SEEG 或 EEG 数据，并在大规模现实世界数据上进行了癫痫检测实验，表明我们的模型优于现有的一些时间序列自监督和无监督模型，并具有在临床实践中被部署的能力。